References |
| Last Updated: August 2, 2010 |
|
Dealing with a data dilemma. (2008). Nat. Rev. Drug. Discov. 7, 632-633.
Austin, C.P., Brady, L.S., Insel, T.R. & Collins, F.S. (2004). NIH Molecular Libraries Initiative. Science. 306, 1138-1139.
Huang, R., Southall, N., Xia, M., Cho, M.H., Jadhav, A., Nguyen, D.T., Inglese, J., Tice, R.R. & Austin, C.P. (2009). Weighted feature significance: A simple, interpretable model of compound toxicity based on the statistical enrichment of structural features. Toxicol. Sci. 112, 385-393.
Kaiser, J. (2008). Molecular biology. Industrial-style screening meets academic biology. Science. 321, 764-766.
Kim, S., Dere, E., Burgoon, L.D., Chang, C.C. & Zacharewski, T.R. (2009). Comparative analysis of AhR-mediated TCDD-elicited gene expression in human liver adult stem cells. Toxicol. Sci. 112, 229-244.
Lazo, J.S. (2006). Roadmap or roadkill: A pharmacologist's analysis of the NIH Molecular Libraries Initiative. Mol. Interv. 6, 240-243.
Miller, S.C., Huang, R., Sakamuru, S., Shukla, S.J., Attene-Ramos, M.S., Shinn, P., Van Leer, D., Leister, W., Austin, C.P. & Xia, M. (2010). Identification of known drugs that act as inhibitors of NF-kappaB signaling and their mechanism of action. Biochem. Pharmacol. 79, 1272-1280.
Rodgers, A.D., Zhu, H., Fourches, D., Rusyn, I. & Tropsha, A. (2010). Modeling liver-related adverse effects of drugs using knearest neighbor quantitative structure-activity relationship method. Chem. Res. Toxicol. 23, 724-732.
Shaw, P.J., Ditewig, A.C., Waring, J.F., Liguori, M.J., Blomme, E.A., Ganey, P.E. & Roth, R.A. (2009). Coexposure of mice to trovafloxacin and lipopolysaccharide, a model of idiosyncratic hepatotoxicity, results in a unique gene expression profile and interferon gamma-dependent liver injury. Toxicol. Sci. 107, 270-280.
Shukla, S. (2009). A New Perspective on the Past, Present and Future of Toxicity Testing. AltTox.org. Available here.
Thomas, C.J., Auld, D.S., Huang, R., Huang, W., Jadhav, A., Johnson, R.L., Leister, W., Maloney, D.J., Marugan, J.J., Michael, S., Simeonov, A., Southall, N., Xia, M., Zheng, W., Inglese, J. & Austin, C.P. (2009). The pilot phase of the NIH Chemical Genomics Center. Curr. Top. Med. Chem. 9, 1181-1193.
Zerhouni, E. (2003). Medicine. The NIH Roadmap. Science. 302, 63-72.
|