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Non-animal Methods for Toxicity Testing

References


Last Updated: December 6, 2007
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Aptula, A.O. & Roberts, D.W. (2006). Mechanistic applicability domains for nonanimal-based prediction of toxicological end points: general principles and application to reactive toxicity. Chem. Res. Toxicol. 19, 1097-1105.

Contrera, J.F., Matthews, E.J., Kruhlak, N.L. & Benz, R.D. (2005). In silico screening of chemicals for bacterial mutagenicity using electrotopological E-state indices and MDL QSAR software. Regul. Toxicol. Pharmacol. 43, 313-323.

Cronin, M.T.D., Jaworska, J.S., Walker, J.D., et al. (2003). Use of quantitative structure-activity relationships in international decision-making frameworks to predict health effects of chemical substances. Environ. Health Perspect. 22, 1391-1401.

Gerberick, G.F., Ryan, C.A., Kern, P.S., et al. (2005). Compilation of historical local lymph node data for evaluation of skin sensitization alternative methods. Dermatitis. 16, 157-202.

Jaworska, J.S., Comber, M., Auer, C. & van Leeuwen, C.J. (2003). Summary of a workshop on regulatory acceptance of (Q)SARs for human health and environmental endpoints. Environ. Health Perspect. 22, 1358-1360.

OECD. (2007). Guidance on grouping of chemicals. Series on Testing & Assessment No. 80. Available here.

Patlewicz, G., Aptula, A.O., Uriarte, E., et al. (2007a). An evaluation of selected global (Q)SARs/expert systems for the prediction of skin sensitisation potential. SAR QSAR Environ. Res. 18, 515-541.

Patlewicz, G., Aptula, A.O., Roberts D.W. & Uriarte, E. (2007b). A mini review of available (Q)SARs and Expert systems for skin sensitisation. QSAR & Comb. Sci. in press.

Roberts, D.W. & Williams, D.L. (1982). The derivation of quantitative correlations between skin sensitisation and physico–chemical parameters for alkylating agents and their application to experimental data for sultones. J. Theo. Biol. 99, 807-825.

Roberts, D.W., Aptula, A.O., Cronin, M.T., et al. (2007a). Global (Q)SARs for skin sensitisation: Assessment against OECD principles. SAR QSAR Environ. Res. 18, 343-365.

Roberts, D.W., Patlewicz, G., Kern, P.S., et al. (2007b). Mechanistic applicability domain classification of a local lymph node assay dataset for skin sensitization. Chem. Res. Toxicol. 20, 1019-1030.

Schultz, T.W. & Seward, J.R. (2000). Health-effects related structure-toxicity relationships: A paradigm for the first decade of the new millennium. Sci. Total Environ. 249, 73-84.

Worth, A.P., Hartung, T. & Van Leeuwen, C.J. (2004). The role of the European Centre for the Validation of Alternative Methods (ECVAM) in the validation of (Q)SARs. SAR QSAR Environ. Res. 15, 345-358.

Worth, A.P., Bassan, A., De Bruijn, J., et al. (2007). The role of the European Chemicals Bureau in promoting the regulatory use of (Q)SAR methods. SAR QSAR Environ. Res. 18, 111-125.