Chantra Eskes, Ph.D. worked for many years at the European Center for the Validation of Alternative Methods (ECVAM) where she was responsible for the area of eye irritation, and served as scientific officer for the cosmetics and topical toxicity areas. She comes from a Dutch and Brazilian background, and obtained an Engineer and Master Degrees in Food Sciences and Technology in France, followed by a Ph.D. on in vitro neurotoxicology obtained at the faculty of medicine of Lausanne in Switzerland.
At ECVAM, her work consisted in the coordination and management of validation studies on alternative methods for eye and skin irritation, and on the regulatory issues related to the EU Cosmetics Directive. Her activities contributed to the evaluation of 15 alternatives to animal testing, the participation in four international validation studies, six alternative test methods being validated, one EU test guideline adopted on a replacement alternative test method to skin irritation testing, and two OECD test guidelines accepted as partial replacement alternatives for eye irritation testing. For her contributions, she has been awarded the European Commission Joint Research Center Excellence Award for the Support to EU Policy in 2009.
Currently Chantra acts as an independent consultant on in vitro toxicology for regulatory and industrial purposes. She’s editor, author, and co-author of a number of scientific monographs. She’s also on the Executive Board from the European Society of In Vitro Toxicology (ESTIV), and acts as reviewer for several scientific journals in the field of in vitro toxicology.
Dr. Chantra Eskes
Email: eskesch@yahoo.com
Jadir Nunes received a Bachelors degree in Pharmacy and Biochemistry and a Masters and Ph.D. in Pharmacotechnics / Cosmetic Sciences (USP), all from the University of São Paulo (USP). Post graduation Dr. Nunes studied Marketing – Latu Sensu (ESPM), as well as several short courses/seminars and training programs attended in Oxford (England), Dusseldorf (Germany), Cannes, Bordeaux (France), Brussels (Belgium) and North Carolina, New Jersey (USA). Dr. Nunes’ professional career developed in the areas of research, development, quality control and clinical evaluations of cosmetic, pharmaceutical products and ingredients, for national and multinational companies, such as Johnson & Johnson, Schering-Plough, Natura, Chemyunion, Evic Brasil and Arch Chemicals. Currently Dr. Nunes is Director of R&D Latin America of Stiefel/GSK Company, ABC Vice President – Brazilian Society of Cosmetic Sciences, and Presidium Member of the International Federation Societies of Cosmetic Chemists.
Dr. Jadir Nunes
Email: jnunes@stiefel.com
Dermeval de Carvalho is a pharmacist, retired Professor of Toxicology at the College of Pharmacy, Ribeirao Preto Campus, University of Sao Paulo, Brasil, and Scientific Director of Biotox Consultant (Brasil).
Dr. Dermaval de Carvalho
Email: biotox@biotox.com.br
Ekaterina Akimovna Botovchenco Rivera is a veterinarian, member of the ad hoc group on laboratory animal welfare OIE/OMSA(Organization Mondiale de la Santé Animale) in Paris, Director of Laboratory Animal House/University of Goiás-UFG (Brasil), and the Brazil representative to the International Council on Laboratory Animal Science. Dr. Rivera was a consultant for the Brazilian Environmental Agency (IBAMA) on laboratory animal tests (1997-2005).
Dr. Ekaterina Rivera
Email: e.rivera@uol.com.br
Thomas Hartung, M.D., Ph.D. is the new Director of the Center for Alternatives to Animal Testing (CAAT) and the inaugural Doerenkamp-Zbinden Chair for Evidence-based Toxicology in the Department of Environmental Health Sciences at the Johns Hopkins University Bloomberg School of Public Health.
In 1991, Dr. Hartung received a Ph.D. in Biochemical Pharmacology from the University of Konstanz, Germany, and an M.D. in Toxicology in 1992 from the University of Tubingen. He completed his medical internship at the University of Freiburg in surgery at the hospital of Singen, Germany.
Dr. Hartung joined the faculty at University of Konstanz in 1994, where he served as an Assistant Professor of Biochemical Pharmacology until 1999, and then as an Associate Professor until 2002. He has been an honorary full professor of Pharmacology at Konstanz since 2003. From 1996 to 2002, Dr. Hartung also served as the CEO of the Steinbeis Technology Transfer Center for In Vitro Pharmacology and Toxicology (InPuT).
In 2002, Dr. Hartung became the Head of the European Centre for Alternative Methods (ECVAM) at the European Commission Joint Research Centre in Italy. As Head of ECVAM, he was integral in accelerating the alternative methods validation process, and in establishing a network of more than 400 experts from all stakeholder groups to facilitate global regulatory harmonization in toxicity testing.
Dr. Thomas Hartung
Johns Hopkins Center for Alternatives to Animal Testing
615 N Wolfe Street, W7032
Baltimore, MD 21205
Email: thartung@jhsph.edu
Sandra Coecke (F) is by training a University Engineer with specialisation in Biotechnology. She has a Ph.D. in Medicine and Pharmaceutical Sciences (Vrije Universiteit Brussels) exploring an in vitro approach to study hormonal regulation of the biotransformation enzymes flavin-containing monooxygenase and glutathione S-transferases in rat liver. She was responsible for the setting up of the In Vitro Toxicology Laboratory at Janssen Pharmaceutica, Belgium, in 1993. In 1994 she was awarded the International Prize from the Foundation for the Substitution of Animal Experimentation, in Luxembourg, based on her work in the field of metabolism and novel in vitro cell culture systems in general. In 1996 she joined the European Centre for the Validation of Alternative Methods, European Commission (EC), Joint Research Centre (JRC), Ispra, Italy. Currently, she is heading the JRC competence group on In-house Validation and Training at the EC JRC Institute for Health and Consumer Protection and is responsible for all validation studies carried out in-house. A Chemical Repository is hosted in her group. With over 20 years experience in in vitro toxicology and over 80 papers on in vitro toxicology, she acquired a strong research background in the fields of in vitro metabolism/xenobiotic biotransformation in hepatocyte cultures, in vitro neurotoxicity/developmental neurotoxicity and in vitro topical toxicity (eye and skin irritation) test models, new advanced technologies in in vitro toxicology testing systems, quality control and the management of ongoing large international collaborative European research projects (Acutetox-in vitro acute toxicity integrated testing strategy, Vitrocellomics-omics and stem cell-based technologies, and Artemis- in vitro neutral tissue system for replacement of transgenic animals with memory/learning deficiencies). She also has run several pre-validation and formal validation studies.
Dr. Sandra Coecke
EC-Joint Research Centre, Ispra site
Via Enrico Fermi 2749
I-21027 Ispra (VA), Italy
Email: sandra.coecke@jrc.ec.europa.eu
Joachim Kreysa, Ph.D., joined the European Commission in 1985, working for 10 years in research management. This was followed by 5 years as scientific secretary of the Scientific Steering Committee that advised the Commission on BSE and similar highly sensitive matters, including overseeing the validation of BSE tests. Thereafter he managed development projects, ran a competition task force, and helped set-up the European Chemicals Agency in Helsinki, the centre-piece of REACH, later joining the founding team as Director for Cooperation of ECHA, being responsible for setting up and running the REACH-Helpdesks and preparing guidance for industry, setting-up the Agency's scientific committees, and creating the communication unit of ECHA. Since November, 2008 he heads the In Vitro Methods Unit of the Institute for Health and Consumer Protection IHCP of the Joint Research Center and is also responsible for ECVAM, which is now a Policy Support Action of the IHCP.
Dr. Joachim Kreysa
Directorate General JRC
B-1049 Brussels BELGIUM
Email: joachim.kreysa@ec.europa.eu
Vanessa de Moura Sá Rocha received a Bachelors degree in Veterinarian, a Masters in Pathology, and a Ph.D. in Sciences from the University of São Paulo, Brazil. She is responsible for coordination and implementation of studies on alternative methods at Natura, a cosmetic Brazilian Company.
Dr. Vanessa de Moura Sá Rocha
Email: vanessarocha@natura.net
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