In vitro testing and other laboratory services that support the development, use, and/or validation of non-animal test methods. If your lab has experience in conducting inter-laboratory validation of in vitro methods or conducts in vitro testing services, please contact info@alttox.org to be listed here.
4-Front Research, Ltd (Cheshire, UK): consumer healthcare testing company, including human clinical eye and skin irritation testing
Advanced CellSystems (Germany): custom designed in vitro assays using the CellSystems® 3D skin models
ADMET Group (Rockville, Maryland, US): in vitro & in vivo preclinical drug development and drug discovery contract research services; GLP studies
An-eX Analytical Services, Ltd. (Cardiff, UK): dermal research and development including in vitro human skin permeation studies performed according to the OECD 428 and other appropriate guidelines
Apredica (Watertown, Massachusetts, US): in vitro ADME toxicity screening services, including specialty assays such as intranasal and lung absorption and toxicity assays using MatTek's EpiAirway System
APSciences, Inc. (Baltimore, Maryland, US): consulting service for in vitro ADMET for drugs and drug candidates; in vitro ADMET Laboratory Setup Service; contract testing using the in vitro Integrated Multiple Organ Culture (idMOC) technology
Asterand, plc (US and UK): recently merged with Pharmagene; supports human drug discovery by providing human biomaterials (cells, tissues, tissue microarrays, RNA) and preclinical research services using human primary cells & cell lines
Austrian Research Centers (ARC) GmbH: CRO offering in vitro and in vivo toxicology services
BIOalternatives (Gencay, France): a service company offering cell-based assays to support drug and healthcare product development
Biomaterials and Tissue Engineering Centre of Industrial Collaboration (BITECIC Ltd) (Leeds, UK): SimulateTM programme for pre-clinical evaluation of medical devices; CelTisTM programme for proteomics, cell therapy, and tissue engineering using a portfolio of well-characterized, functional human tissues and cell lines
Biopta, Ltd. (Glasgow, UK): contract research services using human tissues
bioskin® (Hamburg, Germany): CRO specializing in dermatology clinical trials for safety, efficacy, and biophysical measurements
BSL BioService Scientific Laboratories GmBH (Germany): contract laboratory for in vitro and in vivo toxicology
Caliper Life Sciences (Hanover, Maryland, US): CRO offering in vitro and in vivo toxicology services
Calvert Laboratories, Inc. (Olyphant, Pennsylvania, US): in vitro & in vivo contract testing for drug development
Capsant Neurotechnologies (UK): target validation platform of in vitro tissue-based screening technologies for CNS drug discovery, including ex vivo tissues (organotypic slices) and in vitro, 3-dimentional models
CeeTox, Inc.: in vitro toxicity screening assays for drug discovery, including: Acute Toxicity Screen; Drug-drug Interaction Tox Screen; CardioTox Panel®
Cellumen (Pittsburgh, Pennsylvania, US): Cellular Systems Biology (CSBTM)-based profiling services and/or licenses for cell lines, next-generation reagents, and multiplexed assays for drug development; specialized services and consulting
Celsis In Vitro Technologies (US, Germany, UK): in vitro ADME-Tox services, standard and custom protocols; hepatocyte cell culture and related customized services
Cenix BioScience (Germany): customized research services for cell-based applications of RNA interference (RNAi) for research and drug discovery; experience in combining high throughput RNAi with high content phenotypic analyses in cultured human and rodent cells
Centre for Advanced Research & Development on Alternative Methods (CARDAM) (Belgium): 
in vitro contract testing, R&D, and related activities and consulting
The Centre for Applied Genomics (Toronto, Canada): genomics services to academic, government, or private sectors clients
Cerep (France, Japan, US): in vitro screening and profiling using proprietary database BioPrint® to model clinical effects of drugs from molecular properties; assay development services
Clinical Research Laboratories, Inc. (Piscataway, New Jersey, US): human clinical trials in dermatology, ophthalmology, and allergy
Consumer Product Testing Co., Inc. (Fairfield, New Jersey, US): in vitro & in vivo contract testing
Dermac Laboratory, Inc. (Stamford, Connecticut, US): novel bioinstrumention techniques and analytical tools for noninvasive assessment of skin and hair properties (human clinical safety/efficacy testing)
EcoArray, Inc. (Alachua, Florida, US): microarray products and services for ecotoxicity and endocrine disruptor testing
EDI GmbH (Germany): ex vivo Instant Leukocyte Culture System; customized cell culture systems and immunoassays; in vitro immunotoxicology and immunopharmacology; co-cultures of immune cells with other tissues
Eggcentris (Brussels, Belgium): in vitro tests to screen compounds for reproductive toxicity (effects on fertility and embryonic development)
Entelos, Inc. (Foster City, California, US): predictive biosimulation using in silico disease models and a virtual patient approach to improve the success rates of clinical trials
Epithelix Sàrl (Switzerland): provides in vitro assays to pharmaceutical, biotech, cosmetic, and chemical industries using their own human cellular models
Exiqon (Vedbaek, Denmark): microRNA profiling services
Eurofins-Biolab (Italy): specialised laboratory for in vitro and in vivo toxicology and ecotoxicology
Fluofarma (France): contract service provider offering High Content Screening (HCS) services for target/drug discovery and in vitro toxicity testing
FRAME Alternatives Laboratory: in vitro methods research and validation studies
GenPharmTox BioTech AG (Germany): offers in vitro and in vivo testing of drugs and chemicals; numerous in vitro toxicology and ADME-Tox methods offered, GLP studies
Iconix Biosciences (Mountain View, California, US): toxicogenomics services to profile drug candidates based on proprietary DrugMatrix® database of microarray and pharmacology data
Institute for In Vitro Sciences (IIVS) (Gaithersburg, Maryland, US): contract laboratory for in vitro toxicology, assay optimization and validation, GLP studies, workshops & training
Linus Pauling Institute, Cancer Chemoprotection Program Core Laboratory (Oregon, US): genetic toxicology testing service for dietary compounds: Salmonella mutagenicity assay (Ames test), single cell gel electrophoresis assay (SCG or Comet assay), micronucleus assay
Marin Biologic Laboratories, Inc. (Tiburon, California, US): contract testing and research laboratory for in vitro toxicology, cell biology, assay development and validation; GLP studies
MB Research Laboratories (Spinnerstown, Pennsylvania, US): contract laboratory for in vitro and in vivo toxicology testing; GLP genetic toxicology assays
Midwest BioResearch (Skokie, Illinois, US): preclinical in vitro and in vivo studies for drug development; cell-based bioassays; GLP genetic toxicology assays and novel screening assays
Miltenyi Biotec (Germany): bioinformatics and gene expression profiling services; manufacture of adult stem cells under cGMP conditions; miRNA expression profiling
North American Science Associates (NAMSA) (Northwood, Ohio, US): CRO offering in vitro and in vivo services, including biocompatibility testing
PerkinElmer (Waltham, Massachusetts, US): cellular assay development service for high sensitivity, high-throughput assays; optimized reporter gene assays; biochemical enzyme and radioligand binding assays
Pharmacelsus (Saarbrücken, Germany): CRO offering in vitro and in vivo toxicology services
Phenion GmbH & Co. KG (Germany): contract laboratory owned by Henkel KGaA; in vitro cell & skin models and human in vivo studies for consumer products
PRACS Institute, Ltd. (Fargo, North Dakota, US): CRO offering pre-clinical, clinical, bioanalytical, and statistical research services to the pharmaceutical, biotechnology and skin care industries
Puracyp (Carlsbad, California, US): receptor activation, cytotoxicity, and species comparison screening services for drug discovery using proprietary cell lines
RegeneMed, Inc. (San Diego, California, US): RegeneTOX, human and animal 3-D liver tissue co-cultures; monolayer cell-based products from the same donor for comparison, stem cells and 3-D tissue; contract testing services for ADMET and efficacy assessment in drug discovery
SafePharm Laboratories Limited (UK, USA, Japan): contract laboratory for in vitro and in vivo safety evaluation of chemicals, pharmaceuticals, agrochemicals, intermediates, and medical devices
SIT Skin Investigation and Technology (Hamburg, Germany): CRO offering in vitro and in vivo dermatological testing services
StratiCELL (Gembloux, BELGIUM): CRO for in vitro regulatory safety testing (e.g. REACH) and in vitro efficacy testing; also manufactures reconstituted skin models
VIB MicroArray Facility (Belgium): academic core facility providing access to a full microarray analysis service
VitroCell Systems (Germany): contract research using human cells; VitroCell chamber for in vitro studies of gases or complex mixtures
Vivacell Biotechnology GmbH (Germany): CRO offering in vitro and in vivo testing services, including GLP in vitro toxicity testing
Xceleron Ltd (York, UK): offers ultrasensitive platform technology of accelerator mass spectrometry in biomedical research and human microdosing to accelerate drug development
XenoTech, LLC (Lenexa, Kansas, US): contract research and testing for in vitro drug metabolism using XenoTech reagents and hepatocytes from human and other species
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