Some of the many suppliers that provide useful in vitro testing supplies, cells lines, and other biological reagents.
In Vitro Test Kits
Advanced CellSystems: CellSystems® 3D skin models: EST-1000 and AST-2000
Aniara: cellular toxicology screening products: Xenometrix test systems for mutagenicity; cytotoxicity high throughput screening test kits utilizing various endpoints
APSciences: Integrated Multiple Organ Culture (idMOC), a test platform using primary human, rat, or mouse cells from multiple organs which are physically discrete but interconnected by a common medium for studying drug efficacy, metabolism, toxicity
BioSeek, Inc.: BioMAP® Systems - primary, human cell systems that generate a unique signature of the human biological response for predicting mechanisms and efficacy; BioMap profiles can be compared to company database
Celsis In Vitro Technologies: InVitroSomesTM, human and animal hepatocytes, microsomes, and media for in vitro ADME-Tox; human renal proximal tubule cells and media; Caco-2 cell assay kits
Epithelix Sàrl: in vitro 2D and 3D models of primary human cells: airway epithelium of different origin, keratinocytes and dermal fibroblasts
Gentronix: GreenScreen HC human cell-based genotoxicity screening assay; GreenScreen GC eukaryotic genotoxicity and cytotoxicity assay for simple and rapid screening of lead compounds
In Vitro International: acellular in vitro tests: Corrositex dermal corrosion testing assay; Irritection Assay System for ocular and dermal irritation
Lonza Group Ltd: human corneal epithelial model; bovine blood brain barrier system; renal epithelial cell model
MatTek Corporation: human cell-based test kits include skin, ocular, trachael/bronchial, ectocervico-vaginal, oral epithelial, and dendritic cells, for toxicity testing, research, and drug development; some models, like EpiDerm, are validated
MD Biosciences: cell based assays such as ImmuneProfilerTM for screening of anti-inflammatory properties of substances
MultiCell Technologies, Inc.: predictive hepatotoxicity model consisting of immortalized human hepatocyte cell lines and serum-free MFETM culture medium to screen new drug entities for their impact upon CYP induction using high throughput assays
RegeneMed, Inc.: RegeneTOX, human and animal 3-D liver tissue co-cultures; monolayer cell-based products from the same donor for comparison; stem cells and 3-D tissues
SimuGen Ltd: first product in 2008 will be novel hepatotoxicity platform to predict 10 sub-types of liver toxicity for test chemicals
SkinEthic Laboratories: human epidermal and epithelial models for in vitro test applications for the pharmaceutical, chemical, and consumer product industry; some models, like Episkin, are validated
XenoTech, LLC: products for in vitro drug metabolism-related research: microsomes, cryopreserved hepatocytes from human and other species, CYP antibodies directed against CYP enzymes, and more
Cells and Tissues
ADMET Technologies: cell-based products for drug discovery: characterized, fresh or cryopreserved, primary human hepatocytes available in various plated formats; non-parenchymal liver cells; liver RNA and microsomes; 3D liver bioreactor (in development)
American Type Culture Collection (ATCC): supplies many types of cells lines and bioproducts
Asterand, plc.: provides human biomaterials for drug testing (human primary cells & cell lines, RNA, tissue microarrays, frozen & fixed human tissues)
ATCC-LCG Promochem Partnership: facilitates distribution of ATCC cultures and bioproducts to life science researchers in Europe
BioE, Inc.: Multi-Lineage Progenitor CellTM, a human umbilical cord blood-derived, clonal, multipotent stem cell line; unique cell reagents
Cascade Biologics: keratinocytes and other epithelial cells, endothelial cells, fibroblasts, etc.
Cell Line Database
European Collection of Cell Cultures (ECACC)
German Collection of Micro-Organisms and Cell Cultures
Lonza Group Ltd: primary human and animal cells with customized media systems, Clonetics® and Poietics® Cell Systems
Millipore Corporation: many cell lines and media
Musculoskeletal Transplant Foundation (MTF): supplies pieces of human bone, skin, and other tissues, and FlexHD, an acellular dermal matrix, primarily for surgery
National Cancer Institute (NCI): tissue, cell lines, databases, arrays, etc. primarily for cancer research
National Cell Culture Centre (NCCC): division of Biovest International; provides customized, large scale cell culture services
National Disease Research Interchange (NDRI): human tissues, organs, and derivatives for research
National Human Neural Stem Cell Bank: provides neural stem cells harvested from the post-natal, post-mortem, human and animal brain to the research community for stem cell research; sponsored by the Children’s Hospital of Orange County
National Stem Cell Bank (NSCB) at WiCell: established to acquire, characterize and distribute the 21 human embryonic stem cell lines and their sub-clones to federally funded research programs; they currently have 13 of the 21 cell lines in the federal registry
NIH Human Embryonic Stem Cell Registry: lists the derivations of stem cells that are eligible for federal funding and provides contact information for acquiring the cell lines
OnCore UK: human specimens for cancer research
ProBioGen: specializes in mammalian cell engineering and cell culture: design of custom immortalized cell lines for vaccine and protein production, or for other customer needs
Puracyp: human hepatic microsomes and reagents for drug metabolism studies
tebu-bio laboratories: various cryopreserved primary cells; cell biology services such as cell amplification, differentiation, transfection, mycoplasma testing, establishes cellular models overexpressing or silencing a protein of interest
UK Human Tissue Bank: not-for-profit organization that provides human tissues for biomedical research
UK Stem Cell Bank
Zen Bio: human adult stem cells, preadipocytes, adipocytes, primary human hepatocytes; specialized media
Media & Cell Reagents
Cell Preservation Solutions, LLC: develops novel solutions for preserving cells and tissues, and their storage and transportation (including stem cells); develops optimized mediums; provides DMSO-free cryopreservation solutions, and animal protein-free and serum-free media
Invitrogen: Gibco® Cell Culture Systems includes serum-free and specialty cell culture media and reagents' 3D cell culture products; stem cell reagents and protocols
Lonza Group Ltd: serum-free media, cell culture reagents, cell stains
Millipore Corporation: HEScGRO animal component-free medium for culturing human embryonic stem cells in their undifferentiated state
StemCell Technologies, Inc.: provides specialized media and cell separation products and contract services
Worthington Biochemical Corporation: Hepatocyte Isolation System provides preoptimized combination of enzymes, buffers, and culture media to minimize lot-to-lot variation and improve quality of isolated hepatocytes; Animal Origin Free (AOF) enzymes for biopharma & vaccine production applications
ZET Serum Free Cell Culture Media - Updated Product Guide 1/2004-05: provides sources for obtaining animal-free cell culture media and reagents
Other Supplies & Reagents
AbD Serotec: research and diagnostic antibodies
Affymetrix: DNA chips and microarrays
Amaxa Biosystems: Nucleofection transfection technology; cell database providing optimal transfection conditions for 570 types of cells
Applied Biosystems: instruments, consumables, software, and services for analyzing nucleic acids (DNA and RNA), small molecules, and proteins
BD Biosciences: products for research include antibodies, and reagents for western blotting, immunofluorescence, ELISA; instrumentation and reagents for flow cytometry
Bellbrook Labs: TranscreenerTM Assay Platform, a HTS platform using proprietary fluorescent detection for screening families of enzymes at one time; uses microfluidics to bring cellular models into a fully automated high throughput environment
BioAssay Systems: biochemical and cell-based assays for both routine laboratory testing and high-throughput drug discovery: oxidative stress, cytotoxicity, cell proliferation, enzyme assays, reporter gene assays
Biocompare: large array of life science products and information
Biontex Laboratories: mammalian cell transfection reagents
Cell Signaling Technology: reagents and assays for studying cell signaling pathways
CellASIC: microfluidic platforms for cell and tissue based applications; innovative approach enables cells to be maintained in a more biologically relevant condition
Cellectricon: microfluidic biochips as miniaturized cell-based screening devices: CellaxessTM electroporation technology for transfection of tissue explants and adherent cells; DynaflowTM System for ion channel drug discovery
Cellomics, Inc.: proprietary platforms for cell-based assays
Cell Technology, Inc.: reagents and assay kits for cell-based assays
CompuCyte Corporation: Laser scanning Cytometry instrumentation for cell- and tissue-based analysis; advanced software tools for combining high-content quantitative data analysis with images (morphology)
EcoArray, Inc.: microarrays for ecotoxicity and endocrine disruptor testing: fathead minnow oligonucleotide arrays; reagents & solutions; use of EcoArray database for data interpretation, and discounts for participation in data sharing program to build capacity of predictive company database
EMD Biosciences: Calbiochem, Novabiochem, and Novagen research reagents and assays
Exiqon: mRNA and microRNA research reagents and resources; bioinformatics tools ands services for probe design
FiberCell Systems, Inc.: hollow fiber cartridge systems for in vitro toxicology testing: used to model pharmacologic bio-availability and to culture epithelial cells
Guava Technologies: benchtop flow cytometry systems, reagents, and software; cell cycle assay for cell cycle phase analysis at the benchtop
Invitrogen: research supplies, tools, protocols, Gibco cell culture systems, human biological pathway maps
LabX.com: a media service for the exchange of scientific equipment, where buyers and sellers of new, used, surplus, and refurbished scientific and laboratory equipment can find items, negotiate terms, and complete transactions online
Lonza: cell viability and toxicology assays
Luminex Corporation: xMAP® technology bioassay platform; multiplexing (multiple unique assays) within a single sample
Millipore Corporation: research and cell culture supplies & reagents
Miltenyi Biotec: products for cell biology, immunology, regenerative medicine, and molecular biology
National Institute for Biological Standards and Control (NIBSC): provides International Biological Standards and other biological reference materials that are independently certified to the international quality standard BS EN ISO 9001:2000
OriGene Technologies: tissue qPCR arrays; transfections arrays; transfection reagents
Oxford Biomedical Research: biochemical assay kits, antibodies, cDNA probes, etc.
ProBioGen: development of custom cell lines; in vitro production of monoclonal antibodies & adaptation to serum-free media
Promega: bioluminescent cytochrome P450 assays; cellular and genomic assay reagents & kits; protocols; online tools
R&D Systems: supplier of biological and research products, including antibodies and ELISA kits
Sigma Aldrich: antibodies, media, chemicals, other research reagents
tebu-bio laboratories: reagents for cell biology, drug discovery, in vitro ADME-Tox; laboratory services
Trevigen, Inc.: products for research: DNA damage, apoptosis, molecular biology, cell differentiation, angiogenesis
VitroCell Systems: VitroCell for in vitro culture and exposure to gases or complex mixtures
Software
ADMET PredictorTM: computer software for advanced predictive modeling of ADME/Tox properties from molecular structures; builds predictive models of new properties from user's data
Aniara CelTox Software: for cytotoxicity analysis
Ariadne Genomics: Pathway Studio software for pathway and molecular interaction analysis
ArrayTrack: utilized by US FDA for review of genomic data submissions; integrated solution for managing, analyzing, and interpreting microarray gene expression data; provides statistical and visualization tools, and functional information about genes, proteins, and pathways for biological interpretation
Biocompare: pathway analysis and genomic sequence analysis software
Biographics Laboratory 3R (Biograf 3R) (Basel, Switzerland): software products for computational methods to replace animal testing
Cellnomica: software for modeling and simulation of multicellular systems such as tissue, organs, and organisms
CombiStats: computer program for statistical analysis of data from biological dilution assays or potency assays; can perform calculations according to: parallel line, slope ratio, probit, 4-parameter logistic curve, and more models
Decision Forest: novel pattern recognition method for analysis of microarray, SELDI-TOF MS, and SAR data
Decisioneering: risk analysis and data simulation software
DiscoveryQuantTM Software (Applied Biosystems): mass spectrometry software for early high-throughput ADME testing to improve speed and efficiency of drug candidate analyses
Endocrine Disruptor Knowledge Base: scientific resources including a biological activity database, QSAR training sets, and computational models to predict estrogen and androgen activity
US EPA ECOSAR (Ecological Structure Activity Relationships): program to estimate the toxicity of industrial chemicals discharged into water to aquatic organisms such as fish, invertebrates, and algae; toxicity is predicted using Structure Activity Relationships
US EPA Exposure Assessment Tools & Models
Foodrisk.org: exposure, dose-response, statistical modeling and simulation tools, and more
Foodrisk.org: risk analysis tools and programs
GlodSim: simulation software for decision and risk analysis
Ingenuity Pathway Analysis (IPA): chemical pathway analysis software and database: build pathways, assess toxicity profiles, prioritize biomarkers, metabolite data analysis
JMP: statistical software
Lhasa Limited: non-profit company specializing in the development of expert computer systems for toxicity and metabolism prediction which include Derek for Windows, Meteor and Vitic
MultiCASE, Inc.: computer programs designed to assess the potential pharmacological activity, toxicity, and metabolic transformation of new chemicals
NIEHS: free software for genomics, biostatistics, molecular biology, and more
PBT Profiler: developed as a voluntary screening tool to identify Pollution Prevention (P2) opportunities for chemicals without experimental data; uses a subset of P2 Assessment Framework computer-based tools to help identify chemicals that potentially may persist, bioaccumulate, and be toxic to aquatic life
Premier Biosoft International: lifescience software for microarrays, PCR, primer design, and more; bioinformatics software development and assay design services
Risk Assessment Information System: various risk assessment tools
SAS Institute, Inc.: data analysis software: statistical and simulation
Simulations Plus, Inc.: ADMET PredictorTM software; GastroPlusTM software for oral absorption and pharmacokinetic simulation
Syracuse Research Corporation: Environmental Science Estimation Software - variety of programs available
tebu-bio laboratories: CacoReady SoftwareTM for analysis and management of data from in vitro studies for prediction of intestinal absorption; Noraymet ADMETM for management of in vitro ADME studies and use of in vitro ADME to predict human pharmacokinetic
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