Clemedson, C., Nordin-Andersson, M., Bjerregaard, H.F., et al. (2002). Development of an in vitro test battery for the estimation of acute human systemic toxicity: An outline of the EDIT project. Evaluation-guided Development of New In Vitro Test Batteries. Altern. Lab. Anim. 30, 313-321.
Clemedson, C., Dierickx, P.J. & Sjöström, M. (2003). The prediction of human acute systemic toxicity by the EDIT/MEIC in vitro test battery: The importance of protein binding and of partitioning into lipids. Altern. Lab. Anim. 31, 245-256.
Clemedson, C, Kolman, A. & Forsby, A. (2007). The integrated acute systemic toxicity project (ACuteTox) for the optimisation and validation of alternative in vitro tests. Altern. Lab. Anim. 35, 33-38.
ECVAM. (2002). Acute lethal toxicity. Altern. Lab. Anim. 30, Suppl. 1, 27-33.
ECVAM. (2005). Executive summary. Altern. Lab. Anim. 33, Suppl.1, 7-18.
Freidig, A.P., Dekkers, S., Verwei, M., et al. (2007). Development of a QSAR for worst case estimates of acute toxicity of chemically reactive compounds. Toxicol. Lett. 170, 214-222.
Gennari, A., van den Berghe, C., Casati, S., et al. (2004). Strategies to replace in vivo acute systemic toxicity testing: The report and recommendations of ECVAM Workshop 50. Altern. Lab. Anim. 32, 437-459.
Gribaldo, L., Gennari, A., Blackburn, K., et al. (2005). Acute Toxicity. Altern. Lab. Anim. 33, Suppl. 1, 27-34.
Gülden, M., Mörchel, S. & Seibert, H. (2001). Factors influencing nominal effective concentrations of chemical compounds in vitro: Cell concentration. Toxicol. In Vitro. 15, 233-243.
Gülden, M., Dierickx, P. & Seibert, H. (2006). Validation of a prediction model for estimating serum concentrations of chemicals which are equivalent to toxic concentrations in vitro. Toxicol. In Vitro. 20, 1114-1124.
Halle, W. (2003). The Registry of Cytotoxicity: Toxicity testing in cell cultures to predict acute toxicity (LD50) and to reduce testing in animals. Altern. Lab. Anim. 31, 89-198.
ICCVAM. (2001). Report of the international workshop on in vitro methods for assessing acute systemic toxicity. NIH publication No. 01-4499. Available here.
King, A.V. & Jones, P.A. (2003). In-house assessment of a modified in vitro cytotoxicity assay for higher throughput estimation of acute toxicity. Toxicol. In Vitro. 17, 717–722.
O'Brien, P.J., Irwin, W., Diaz, D., et al. (2006). High concordance of drug-induced human hepatotoxicity with in vitro cytotoxicity measured in a novel cell-based model using high content screening. Arch. Toxicol. 80, 580-604.
O'Brien, P. & Haskins, J.R. (2007). In vitro cytotoxicity assessment. Methods Mol. Biol. 356, 415-425.
Schlede, E., Genschow, E., Spielmann, H., et al. (2005). Oral acute toxic class method: A successful alternative to the oral LD50 test. Regul. Toxicol. Pharmacol. 42, 15-23.
Siebert, H., Balls, M., Fentem, J.H., et al. (1996). Acute toxicity testing in vitro and the classification and labelling of chemicals. Altern. Lab. Anim. 24, 499-510.
Seibert, H., Mörchel, S. & Gülden, M. (2002). Factors influencing nominal effective concentrations of chemical compounds in vitro: Medium protein concentration. Toxicol. In Vitro. 16, 289-297.
Spielmann, H., Genschow, E., Liebsch, M. & Halle, W. (1999). Determination of the starting dose for acute oral toxicity (LD50) testing in the Up and Down Procedure (UDP) from cytotoxicity data. Altern. Lab. Anim. 27, 957-966.
Stallard, N., Whitehead, A. & Indans, I. (2003). Statistical evaluation of the fixed concentration procedure for acute inhalation toxicity assessment. Hum. Exp. Toxicol. 22, 575-585.
Stallard, N., Whitehead, A. & Indans, I. (2004). Statistical evaluation of an acute dermal toxicity test using the dermal fixed dose procedure. Hum. Exp. Toxicol. 23, 405-412.
United Nations Economic Commission for Europe (UNECE). (2004). Globally harmonized system of classification and labeling of chemicals (GHS). Part 3, Health and environmental hazards. Chapter 3.1, Acute toxicity. Available here.
Walum, E., Hedander, J. & Garberg, P. (2005). Research perspectives for pre-screening alternatives to animal experimentation. On the relevance of cytotoxicity measurements, barrier passage determinations and high throughput screening in vitro to select potentially hazardous compounds in large sets of chemicals. Toxicol. Appl. Pharmacol. 207, Suppl. 2, 393-397.
Whitehead, A. & Stallard, N. (2004). Opportunities for reduction in acute toxicity testing via improved design. Altern. Lab. Anim. 32, Suppl. 2, 73-80.
Xu, J.J., Diaz, D. & O'Brien, P.J. (2004). Applications of cytotoxicity assays and pre-lethal mechanistic assays for assessment of human hepatotoxicity potential. Chem. Biol. Interact. 150, 115-128.
|
