Combes, R., Balls, M., Curren, R., et al. (1999). Cell transformation assays as predictors of human carcinogenicity. ECVAM Workshop Report 39. Altern. Lab. Anim. 27, 745-767.
Cronin, M.T.D., Jaworska, J.S., Walker, J.D., et al. (2003). Use of QSARs in International Decision-Making Frameworks to Predict Health Effects of Chemical Substances. Environ. Health Perspect. 111, 1391-1401. Available here.
ECVAM. (2002). Genotoxicity and carcinogenicity. Altern. Lab. Anim. 30, Suppl. 1, 83-93.
Goodman, J.I. (2001). A perspective on current and future uses of alternative models for carcinogenicity testing. Toxicol. Pathol. 29, Suppl., 173-176.
Hendrix, M.J., Seftor, E.A., Seftor, R.E., et al. (2007). Reprogramming metastatic tumour cells with embryonic microenvironments. Nat. Rev. Cancer. 7, 246-255.
ILSI-HESI. (2003). Workshop on the utility of transgenic assays for risk assessment. Washington, DC. Available here.
Jena, G.B., Kaul, C.L. & Ramarao, P. (2005). Regulatory requirements and ICH guidelines on carcinogenicity testing of pharmaceuticals: A review on current status. Indian J. Pharmacol. 37, 209-222. Available here.
Kirkland, D., Aardema, M., Henderson, L. & Müller, L. (2005). Evaluation of the ability of a battery of three in vitro genotoxicity tests to discriminate rodent carcinogens and non-carcinogens. I. Sensitivity, specificity and relative predictivity. Mutat. Res. 584, 1-256.
Kirkland, D., Aardema, M., Müller, L. & Hayashi, M. (2006). Evaluation of the ability of a battery of three in vitro genotoxicity tests to discriminate rodent carcinogens and non-carcinogens II. Further analysis of mammalian cell results, relative predictivity and tumour profiles. Mutat. Res. 608, 29-42.
MacDonald, J., French, J.E., Gerson, R.J., et al. (2004). The utility of genetically modified mouse assays for identifying human carcinogens. The Alternatives to Carcinogenicity Testing Committee ILSI-HESI. Toxicol. Sci. 77, 188-194.
Maurici, D., Aardema, M., Corvi, R., et al. (2005a). Carcinogenicity. Altern. Lab. Anim. 33, Suppl. 1, 177-182.
Maurici, D., Aardema, M., Corvi, R., et al. (2005b). Genotoxicity and mutagenicity. Altern. Lab. Anim. 33, Suppl. 1, 117–130.
Moggs, J.G., Goodman, J.I., Trosko, J.E. & Roberts, R.A. (2004). Epigenetics and cancer: Implications for drug discovery and safety assessment. Toxicol. Appl. Pharmacol. 196, 422-430.
OECD. (2006). Detailed review paper on cell transformation assays for detection of chemical carcinogens. DRP No. 31. Fourth draft version. Available here.
OECD. (2007). Report on the regulatory uses and applications in OECD member countries of (Quantitative) Structure -Activity Relationship [(Q)SAR] models in the assessment of new and existing chemicals, ENV/JM/MONO(2006)25, Series on Testing and Assessment No. 58. Available here.
Robinson, D.E. & MacDonald, J.S. (2001). Background and framework for ILSI's collaborative evaluation program on alternative models for carcinogenicity assessment. International Life Sciences Institute. Toxicol. Pathol. 29, 13-19.
United Nations Economic Commission for Europe (UNECE). (2004). Globally Harmonized System of classification and labeling of chemicals (GHS). Part 3, Health and environmental hazards. Chapter 3.6, Carcinogenicity. Available here.
Young, J., Tong, W., Fang, H., et al. (2004). Building an organ-specific carcinogenic database for SAR analyses. J. Toxicol. Environ. Health A. 67, 1363-1389.
Watson, R.E. & Goodman, J.I. (2002). Epigenetics and DNA methylation come of age in toxicology. Toxicol. Sci. 67, 11-16.
Watson, R.E., McKim, J.M., Cockerell, G.L. & Goodman, J.I. (2004). The value of DNA methylation analysis in basic, initial toxicity assessments. Toxicol. Sci. 79, 178-188.
Carcinogenicity Databases and Other Resources
Carcinogenic Potency Database (CPDB): Easily accessed results of 6,153 experiments on 1,485 chemicals from 1,426 papers and 429 NCI/NTP (National Cancer Institute/National Toxicology program) Technical Reports.
Chemical Carcinogenesis Research Information System (CCRIS): Carcinogenicity and mutagenicity test results for more than 8,000 chemicals.
IARC Monographs on the Evaluation of Carcinogenic Risks to Humans
IARC List of Agents
ILSI-HESI database
Junghans, T.B., Sevin, I.F., Ionin, B. & Seifried, H. (2004). Cancer information resources: Digital and online sources. Toxicol. 198, 177-193.
NTP technical reports and databases
TOXNET Genetic Toxicology Data Bank (GENE-TOX): Peer-reviewed genetic toxicology test data for more than 3,000 chemicals.
US EPA List of Chemicals Evaluated for Carcinogenic Potential
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