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Non-animal Methods for Toxicity Testing

References


Last Updated: December 6, 2007
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Curren, R.D., Mun, G.C., Gibson, D.P. & Aardema, M.J. (2006). Development of a Method for Assessing Micronuclei Induction in a 3-D Human Skin Model EpiDermTM. Mutat. Res. 607, 61-87.

Flamand, N., Marrot, L., Belaidi, J.P., Bourouf, L., Dourille, E., Feltes, M. & Meunier, J.R. (2006). Development of genotoxicity test procedures with Episkin®, a human reconstructed skin model: towards new tools for in vitro risk assessment of dermally applied compound? Mutat. Res. 606, 39-51.

Kirkland, D., Aardema, M., Henderson, L. & Müller, L. (2005). Evaluation of the ability of a battery of 3 in vitro genotoxicity tests to discriminate rodent carcinogens and non-carcinogens. I. Sensitivity, specificity and relative predictivity. Mutat. Res. 584, 1-256.

Kirkland, D., Aardema, M., Müller, L. & Hayashi, M. (2006). Evaluation of the ability of a battery of three in vitro genotoxicity tests to discriminate rodent carcinogens and non-carcinogens: II. Further analysis of mammalian cell results, relative predictivity and tumour profiles. Mutat. Res. 608, 29-42.

Kirkland, D., Pfuhler, S., Tweats, D., Aardema, M., Corvi, R., Darroudi, F., Elhajouji, A., Glatt, H., Hastwell, P., Hayashi, M., Kasper, P., Kirchner, S., Lynch, A., Marzin, D., Maurici, D., Meunier, J.R., Müller, L., Nohynek, G., Parry, J., Parry, E., Thybaud, V., Tice, R., van Benthem, J., Vanparys, P. & White, P. (2007a). How to reduce false positive results when undertaking in vitro genotoxicity testing and thus avoid unnecessary follow-up animal tests: Report of an ECVAM Workshop. Mutat. Res. 628, 31-55.

Kirkland, D.J., Aardema, M., Banduhn, N., Carmichael, P., Fautz, R., Meunier, J.R. & Pfuhler, S. (2007b). In vitro approaches to develop weight of evidence (WoE) and mode of action (MoA) discussions with positive in vitro genotoxicity results. Mutagenesis. 22, 161-175.

Thybaud, V., Aardema, M., Casciano, D., Dellarco, V., Embrye, M., Gollapudi, B., Hayashi, M., Holsapple, M.P., Jacobson-Kram, D., Kasper, P., MacGregor, J.T. & Rees, R. (2007a). Relevance and follow-up of positive results in in vitro genetictoxicity assays: An ILSI-HESI initiative. Mutat. Res. 633, 67–79.

Thybaud, V., Aardema, M.J., Clements, J., Dearfield, K., Galloway, S., Hayashi, M., Jacobson-Kram, D., Kirkland, D., MacGregor, J., Marzin, D., Ohyama, W., Schuler, M., Suzuki, H. & Zeiger, E. (2007b). Strategy for genotoxicity testing: follow-up testing and evaluation of results for positive or equivocal results. Report of IWGT workshop. Mutat. Res. 627, 41–58.