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Non-animal Methods for Toxicity Testing

Neurotoxicity: References


Last Updated: July 20, 2009
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Bal-Price, A.K., Suñol, C., Weiss, D.G., et al. (2008a). Application of in vitro neurotoxicity testing for regulatory purposes: Symposium III summary and research needs. Neurotoxicology. 29, 520-531.

Bal-Price, A.K., Hogberg, H.T., Buzanska, L. & Coecke, S. (2008b). Relevance of in vitro neurotoxicity testing for regulatory requirements: Challenges to be considered. Neurotoxicol. Teratol. (Dec. 24, 2008, Epub ahead of print).

Breier, J.M., De Groot, D., Fritsche, E., et al. (2009). Neural progenitor cells as models for high-throughput screens of developmental neurotoxicity: State of the science. Neurotoxicol. Teratol. (Jun. 23, 2009, Epub ahead of print). Available here.

Breier, J.M., Radio, N.M., Mundy, W.R. & Shafer, T.J. (2008). Development of a high-throughput screening assay for chemical effects on proliferation and viability of immortalized human neural progenitor cells. Toxicol. Sci. 105, 119-133.

Buzanska, L., Habich, A., Jurga, M., et al. (2005). Human cord blood-derived neural stem cell line--possible implementation in studying neurotoxicity. Toxicol. In Vitro. 19, 991-999.

Buzanska, L., Ruiz, A., Zychowicz, M., et al. (2009). Patterned growth and differentiation of human cord blood-derived neural stem cells on bio-functionalized surfaces. Acta Neurobiol. Exp. (Wars) 69, 24-36.

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Coecke, S., Goldberg, A.M., Allen, S., et al. (2007). Workgroup report: Incorporating in vitro alternative methods for developmental neurotoxicity into international hazard and risk assessment strategies. Environ. Health Perspect. 115, 924-931.

Costa, L.G., Fattori, V., Giordano, G. & Vitalone, A. (2007). An in vitro approach to assess the toxicity of certain food contaminants: Methylmercury and polychlorinated biphenyls. Toxicology. 237, 65-76.

Crofton, K.M., Foss, J.A., Hass, U., et al., (2008). Undertaking positive control studies as part of developmental neurotoxicity testing: a report from the ILSI Research Foundation/Risk Science Institute expert working group on neurodevelopmental endpoints. Neurotoxicol. Teratol. 30, 266-287.

Cucullo, L., Hossain, M., Rapp, E., et al. (2007). Development of a humanized in vitro blood-brain barrier model to screen for brain penetration of antiepileptic drugs. Epilepsia. 48, 505-516.

ECVAM. (2002). Target organ and target system toxicity. Altern. Lab. Anim. 30, Suppl. 1, 71-82.

Fitzpatrick, J., Mendez, E. & Walls, I. (2008). Introduction to the ILSI Research Foundation/Risk Science Institute reports from the expert working group on neurodevelopmental endpoints. Neurotoxicol. Teratol. 30, 263-265.

Gartlon, J., Kinsner, A., Bal-Price, A., et al. (2006). Evaluation of a proposed in vitro test strategy using neuronal and non-neuronal cell systems for detecting neurotoxicity. Toxicol. In Vitro. 20, 1569-1581.

Harry, G.J., Billingsley, M., Bruinink, A., et al. (1998). In vitro techniques for the assessment of neurotoxicity. Environ. Health Perspect. 106, Suppl. 1, 131-158.

Harry, G.J. & Tiffany-Castiglioni, E. (2005). Evaluation of neurotoxic potential by use of in vitro systems. Expert Opin. Drug Metab. Toxicol. 1, 701-713.

Holson, R.R., Freshwater, L., Maurissen, J.P., et al. (2008). Statistical issues and techniques appropriate for developmental neurotoxicity testing: A report from the ILSI Research Foundation/Risk Science Institute expert working group on neurodevelopmental endpoints. Neurotoxicol. Teratol. 30, 326-348.

Lein, P., Locke, P. & Goldberg, A. (2007). Meeting report: Alternatives for developmental neurotoxicity testing. Environ. Health Perspect. 115, 764-768

LePage, K.T., Dickey, R.W., Gerwick, W.H., et al. (2005). On the use of neuro-2a neuroblastoma cells versus intact neurons in primary culture for neurotoxicity studies. Crit. Rev. Neurobiol. 17, 27-50.

Li, A.P., Bode, C. & Sakai, Y. (2004). A novel in vitro system, the integrated discrete multiple organ cell culture (IdMOC) system, for the evaluation of human drug toxicity: Comparative cytotoxicity of tamoxifen towards normal human cells from five major organs and MCF-7 adenocarcinoma breast cancer cells. Chem. Biol. Interact. 150, 129-136.

Makris, S.L., Raffaele, K., Allen, S., et al. (2009). A retrospective performance assessment of the developmental neurotoxicity study in support of OECD test guideline 426. Environ. Health Perspect. 117, 17-25.

Mannerström, M., Toimela, T., Ylikomi, T. & Tähti, H. (2006). The combined use of human neural and liver cell lines and mouse hepatocytes improves the predictability of the neurotoxicity of selected drugs. Toxicol. Lett. 165, 195-202.

Meacham, C.A., Freudenrich, T.M., Anderson, W.L., et al. (2005). Accumulation of methylmercury or polychlorinated biphenyls in in vitro models of rat neuronal tissue. Toxicol. Appl. Pharmacol. 205, 177-187.

Mundy, W.R., Freudenrich, T.M., Crofton, K.M. & DeVito, M.J. (2004). Accumulation of PBDE-47 in primary cultures of rat neocortical cells. Toxicol. Sci. 82, 164-169.

Mundy, W.R., Robinette, B., Radio, N.M. & Freudenrich, T.M. (2008). Protein biomarkers associated with growth and synaptogenesis in a cell culture model of neuronal development. Toxicology. 249, 220-229.

Prieto, P., Blaauboer, B.J., de Boer, A.G., et al. (2004). Blood-Brain Barrier in vitro models and their application in toxicology. ECVAM Workshop Report 49. Altern. Lab. Anim. 32, 37-50.

Prieto, P., Clemedson, C., Meneguz, A., et al. (2005). Subacute and subchronic toxicity. Altern. Lab. Anim. 33, Suppl. 1, 109-116.

Radio, N.M., Breier, J.M., Shafer, T.J. & Mundy, W.R. (2008). Assessment of chemical effects on neurite outgrowth in PC12 cells using high content screening. Toxicol. Sci. 105, 106-118.

Radio, N.M., Freudenrich, T.M., Robinette, B.L., et al. (2009). Comparison of PC12 and cerebellar granule cell cultures for evaluating neurite outgrowth using high content analysis. Neurotoxicol. Teratol. (Jun 24, 2009, Epub ahead of print). Available here.

Radio, N.M. & Mundy, W.R. (2008). Developmental neurotoxicity testing in vitro: Models for assessing chemical effects on neurite outgrowth. Neurotoxicology. 29, 361-376.

Raffaele, K.C., Fisher, Jr., J.E. Hancock, S., et al. (2008). Determining normal variability in a developmental neurotoxicity test: A report from the ILSI Research Foundation/Risk Science Institute expert working group on neurodevelopmental endpoints. Neurotoxicol. Teratol. 30, 288-325.

Ravula, S.K., Wang, M.S., McClain, M.A., et al. (2007). Spatiotemporal localization of injury potentials in DRG neurons during vincristine-induced axonal degeneration. Neurosci. Lett. 415, 34-39.

Siddharthan, V., Kim, Y.V., Liu, S. & Kim, K.S. (2007). Human astrocytes/astrocyte-conditioned medium and shear stress enhance the barrier properties of human brain microvascular endothelial cells. Brain Res. 1147, 39-50.

Stummann, T.C., Hareng, L. & Bremer, S. (2009). Hazard assessment of methylmercury toxicity to neuronal induction in embryogenesis using human embryonic stem cells. Toxicology. 257, 117-126.

Suñol, C., Babot, Z., Fonfría, E. et al. (2008). Studies with neuronal cells: From basic studies of mechanisms of neurotoxicity to the prediction of chemical toxicity. Toxicol. In Vitro. 22, 1350-1355.

Suzuki, I. & Yasuda, K. (2007). Detection of tetanus-induced effects in linearly lined-up micropatterned neuronal networks: Application of a multi-electrode array chip combined with agarose microstructures. Biochem. Biophys. Res. Commun. 356, 470-475.

Tähti, H., Nevala, H. & Toimela, T. (2003). Refining in vitro neurotoxicity testing: The development of blood-brain barrier models. Altern. Lab. Anim. 31, 273-276.

Tamm, C., Duckworth, J., Hermanson, O. & Ceccatelli, S. (2006). High susceptibility of neural stem cells to methylmercury toxicity: Effects on cell survival and neuronal differentiation. J. Neurochem. 97, 69-78.

Tyl, R.W., Crofton, K., Moretto, A., et al. (2008). Identification and interpretation of developmental neurotoxicity effects: A report from the ILSI Research Foundation/Risk Science Institute expert working group on neurodevelopmental endpoints. Neurotoxicol. Teratol. 30, 349-381.

van Vliet, E., Morath, S., Eskes, C., et al. (2008). A novel in vitro metabolomics approach for neurotoxicity testing, proof of principle for methyl mercury chloride and caffeine. Neurotoxicology. 29, 1-12.

van Vliet, E., Stoppini, L., Balestrino, M., et al. (2007). Electrophysiological recording of re-aggregating brain cell cultures on multi-electrode arrays to detect acute neurotoxic effects. Neurotoxicology. 28, 1136-1146.

Yang, I.H., Siddique, R., Hosmane, S., et al. (2009). Compartmentalized microfluidic culture platform to study mechanism of paclitaxel-induced axonal degeneration. Exp. Neurol. 218, 124-128.

Zeng, X., Chen, J., Deng, X., et al. (2006). An in vitro model of human dopaminergic neurons derived from embryonic stem cells: MPP+ toxicity and GDNF neuroprotection. Neuropsychopharmacology. 31, 2708-2715.