Author Biography: Coecke & Price |
| Last Updated: December 6, 2007 |
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Sandra Coecke obtained her PhD degree in Pharmaceutical Sciences in 1994 at the Free University of Brussels. In the PhD work, an in vitro approach was used to study hormonal regulation of the biotransformation enzymes flavin-containing monooxygenase and glutathione S-transferases in rat liver.
With over 17 years experience in in vitro toxicology she acquired a strong research background in the fields of in vitro metabolism/xenobiotic biotransformation in hepatocyte cultures, in vitro neurotoxicity and in vitro topical toxicity (eye and skin irritation) test models, new advanced technologies in in vitro toxicology testing systems, quality control and in the management of currently running large international collaborative European research projects. She also has run several prevalidation and formal validation studies.
She joined in 1993 the Janssen Pharmaceutica were she got the lead of the In vitro Toxicology laboratory with focus on in vitro regulatory studies for eye and skin irritation.
In 1994 she was awarded the International Price from Foundation for the Substitution of Animal Experimentation in Luxembourg.
In 1996 she joined the European Centre for the Validation of Alternative Methods, Ispra, Italy where she is responsible for ECVAM's strategic developments with focus on emerging technologies with the potential to optimize and expedite the process of alternative methods and new testing strategies.
Since her start at ECVAM her laboratory projects were mainly focused on development of in vitro neurotoxicity and developmental neurotoxicity models and assuring metabolic competence in in vitro toxicological models.
Sandra Coecke
ECVAM
Institute of Health and Consumer Protection
European Commission Joint Research Centre
21020 ISPRA (VA)
Italy
E-mail: sandra.coecke@jrc.it
Anna Price graduated from the Polish Academy of Sciences, Institute of Pharmacology with a Master of Science in Biology in 1981 and with a PhD in Pharmacology in 1990.
She was awarded several fellowships which allowed her to work as a visiting senior scientist at Utrecht University (Holland), the Joseph Fourier University in Grenoble (France) and the University of London (UK). She also worked at the University of Cambridge (UK), where she continued studies on mechanisms of neuronal cell death. Her research was focused on the physiological and pathological role of nitric oxide in the Central Nervous System.
From 2002 she has been working in ECVAM supervising several research projects in the area of neurotoxcity and developmental neurotoxicity using various in vitro models of primary neuronal and glial cultures (mixed and pure) and different neuronal cell lines as alternative approach to in vivo studies. She is also involved in ECVAM regulatory activities. She serves as an expert in the area of Neurotoxicity testing for FP6 Integrated Projects, Acute-Tox (FP6 IP), and ARTEMIS. She is a Workpackage leader of CNS toxicity testing in Predict-IV (FP7 Iintegrated Project). Recently she is strongly involved in sensor and "omics" technologies (fingerprint, biomarkers profiling, multielectrode arrays, measurements of neuronal electrical activity, surface patterning and image analysis) exploring its relevance as possible endpoints for in vitro neurotoxicity assessment.
Anna Price
ECVAM
Institute of Health and Consumer Protection
European Commission Joint Research Centre
21020 ISPRA (VA)
Italy
E-mail: anna.price@jrc.it | 
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