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Non-animal Methods for Toxicity Testing

Author Biography: Barton

Last Updated: December 6, 2007
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Dr. Barton is a toxicologist with the US EPA developing computational models for use in biologically based dose-response analyses for chemical risk assessment. He specializes in the use of physiologically based pharmacokinetic (PBPK) and pharmacodynamic modeling to address low dose, interspecies, and inter-route extrapolations that critically impact estimating risks. He has evaluated volatile organic compounds, endocrine disrupting chemicals, and perfluorinated alkyl compounds, most recently focusing on comparisons across lifestages. Dr. Barton received a B.S. in Life Sciences from the Massachusetts Institute of Technology, Cambridge, MA in 1982 and a Ph.D. from the Toxicology Program at MIT in 1988. After working for consulting companies for 10 years, he joined US EPA in 1999, where he is currently at the National Center for Computational Toxicology in Research Triangle Park, NC. He is adjunct Assistant Professor in the Curriculum in Toxicology at the University of North Carolina at Chapel Hill. He has published more than 40 articles in the scientific literature on xenobiotic metabolism, PBPK and PD modeling, endocrine disruption, dose response assessment, and risk assessment.

Dr. Hugh A. Barton
US EPA
Office of Research and Development
National Center for Computational Toxicology
Research Triangle Park, NC 27711
E-mail: barton.hugh@epamail.epa.gov