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Non-animal Methods for Toxicity Testing

United States: Programs & Policies

Last Updated: October 15, 2012
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US Federal Government Overview

The United States federal government comprises the executive branch, which includes the president, his or her delegates and cabinet-level agencies; the legislative branch or Congress, which consists of the elected members of the Senate and House of Representatives; and the judicial branch, or court system.


US Regulatory/Research Agencies & Interagency Bodies

Responsibility for implementing and/or enforcing federal law rests with a number of regulatory and research agencies. Many of the agencies with influence on the use of animals and/or alternatives in regulatory toxicology are located within the US Department of Health and Human Services, while others operate independently. In addition, two key interagency bodies have been established to coordinate programs and activities of mutual interest.


US Government Testing Programs

In addition to the day-to-day regulatory and research activities of federal agencies, a number of large-scale data gathering and chemical testing programs have been initiated in the US.


US Pharmacopeia

A nongovernmental, standard-setting organization dedicated to ensuring the quality of all pharmaceuticals, biologics, dietary supplements, and other health care products manufactured and sold in the US.


US Validation Centers

The National Toxicology Program (NTP) Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM) and the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) are the two government entities that comprise the 'national validation center' for the United States.


US 3Rs Centers & Initiatives

In addition to the 3Rs advancement efforts by individual US federal agencies and NICEATM/ICCVAM, several independent nonprofit and academic centers also operate with similar mandates.


US Animal Welfare Oversight

The US system of regulation and oversight of animal care and use for testing and research consists of patchwork of legislative, regulatory, and guidance tools independently established and overseen by various federal agencies and independent scientific bodies.


The Way Forward

A collection of invited commentaries on The Way Forward pertaining to programs & policies in the United States.