Non-animal Methods for Toxicity Testing

The Way Forward

Last Updated: June 11, 2014
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The Way Forward essays are a series of invited expert commentaries exclusively available on the AltTox website.

Many sections of AltTox conclude with one or more of the invited The Way Forward essays, which were written by technical or policy experts in the field covered in that section. The writers, whose brief biographical sketches follow their essays, were all asked to express their views on how best to accelerate progress on developing, validating, and gaining regulatory acceptance of non-animal methods in the topics under consideration. These "Way Forward" commentaries address specific fields of toxicity testing (e.g, neurotoxicity testing), types of non-animal technology applied to toxicity testing (e.g. (Quantitative) Structure-Activity Relationships), and stakeholder policies or programs (e.g., the Interagency Coordinating Committee on the Validation of Alternative Methods). Also included are more broadly focused essays on Overarching Challenges and Opportunities. The commentators were under no obligation to address all aspects of a topic; indeed, many chose to address a few salient aspects of the subject matter. Their views do not necessarily reflect those of the AltTox Management Team.

Readers are invited to discuss these commentaries in The AltTox Forum. Also, readers interested in writing a Way Forward commentary, or in nominating a colleague, should contact the Management Team at We would especially welcome offers to write commentaries on topics that currently have few or no commentaries. Moreover, we will regularly post new commentaries and archive older ones.

Author Guidelines for The Way Forward Essays


Toxicity Endpoints & Tests


Acute Systemic Toxicity


Eye Irritation/Corrosion




Pharmacokinetics & Metabolism

Repeated Dose/Organ Toxicity

Reproductive & Developmental Toxicity

Skin Irritation/Corrosion

Skin Sensitization


Emerging Technologies


-Omics, Computational Biology, & Bioinformatics

Cell-based Technologies

Integrated Testing Strategies & Risk Assessment



Programs & Policies


United States

European Union



Overarching Challenges & Opportunities